P92 C2C AND COLL2-1 BIOMARKERS REVEAL INCREASED TYPE II COLLAGEN CATABOLISM IN BIGLYCAN/FIBROMODULIN DOUBLE DEFICIENT MICE
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منابع مشابه
Collagen catabolism through Coll2-1 and Coll2-1NO2 and myeloperoxidase activity in marathon runners
To determine the influence of marathon on the serum levels of two markers of cartilage degradation, Coll2-1 and its nitrated form, Coll2-1NO2, and of a marker of neutrophils activation, the myeloperoxidase (MPO). Coll2-1, Coll2-1NO2, total and active MPO were measured in 98 marathon runners without joint pain and with an average age of 47 years. Sera were taken at rest right before the departur...
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OBJECTIVE To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). METHODS Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; myeloperoxidase (MPO); a peptide of the alpha-helical region of type II collagen, Coll2-1, and its nitrated form Coll2-1NO(2); a C-terminal neoepitope generated by the collagenase-mediated cl...
متن کاملType Ii Collagen - Induced Arthritis in Mice
The induction of immunological reactivity to type II collagen, a major component of cartilage, has recently been used to establish an experimental model of arthritis in the rat (1). Trentham and colleagues (1) have shown that the intradermal injection of collagen in Freund's complete or incomplete adjuvant elicits an arthritogenic reaction, specifically with native type II collagen. Arthritis o...
متن کاملIncreased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice.
The controlled assembly of collagen monomers into fibrils, with accompanying intermolecular cross-linking by lysyl oxidase-mediated bonds, is vital to the structural and mechanical integrity of connective tissues. This process is influenced by collagen-associated proteins, including small leucine-rich proteins (SLRPs), but the regulatory mechanisms are not well understood. Deficiency in fibromo...
متن کاملOsteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses.
OBJECTIVES To investigate the effects of exercise and osteochondral (OC) injury on type II collagen degradation products (collagenase cleavage neoepitope commercially known as C2C) in synovial fluid (SF) from Thoroughbred (TB) racehorses and to compare these results with radiographic and arthroscopic scores of severity of joint injury. METHODS Metacarpophalangeal/metatarsophalangeal (MCP/MTP)...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2006
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)60544-5